VIP
Research profile · How we handle evidence
VIP (vasoactive intestinal peptide) is a naturally occurring peptide studied for anti-inflammatory signaling and immune modulation.
Evidence Score
Moderate confidence
Category
Therapeutic area
Standard Dose
Daily
Half-life
Plasma elimination
Route
Subcutaneous or Intranasal
Safety Tier
Monitor closely
Overview
VIP is a 28–amino-acid signaling peptide. In research settings it’s discussed for roles in calming inflammatory pathways, supporting immune balance, and relaxing smooth muscle (which can affect airway tone and gut motility). Because it’s a short-lived molecule, most real-world discussion focuses on formulation, delivery route, and tolerated dosing rather than simple “best dose” certainty. Treat this page as educational context, not a recommendation for treating any specific condition.
Mechanism of Action
VIP is a 28–amino-acid signaling peptide. In research settings it’s discussed for roles in calming inflammatory pathways, supporting immune balance, and relaxing smooth muscle (which can affect airway tone and gut motility). Because it’s a short-lived molecule, most real-world discussion focuses on formulation, delivery route, and tolerated dosing rather than simple “best dose” certainty. Treat this page as educational context, not a recommendation for treating any specific condition.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Anti-inflammatory
- Immune regulation
- Tissue protection
- Bronchodilation
Side Effects
- Possible headache or flushing (reported in some clinical contexts)
- Possible low blood pressure (hypotension)
- Route-related irritation can happen depending on formulation
Contraindications
- Pregnant or breastfeeding women
- People who have had significant hypotension with VIP-related products
- Uncontrolled or unstable respiratory disease—use only under clinician guidance
Structure & Sequence
Verified structure
VIP
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2 (28aa)
- Molecular Weight
- 3,323.8 Da
- Chemical Formula
- C147H237N43O43S
- CAS Number
- 40077-57-4
- Reconstituted pH
- 5.7-6.1
- InChIKey
- VBUWHHLIZKOSMS-UHFFFAOYSA-N
Stack & Route Context
Stacks with
- Thymosin Alpha-1
- LL-37
Administration
Subcutaneous or Intranasal
Research Status
Research peptide for inflammatory conditions
Approval Status
Phase2
Sports Legal
Permitted
References
- 1View source
INHALED VASOACTIVE INTESTINAL PEPTIDE (VIP) IMPROVES THE 6-MINUTE WALK TEST AND QUALITY OF LIFE IN PATIENTS WITH COPD: THE VIP/COPD-TRIAL
2017
- 2View source
Structure-activity relationship of vasoactive intestinal peptide (VIP): potent agonists and potential clinical applications
2006
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.