Thymosin Alpha-1
Research profile · How we handle evidence
Thymosin alpha-1 (also called thymalfasin) is a thymic peptide studied for immune modulation. Human research has explored it in different clinical settings, but how well it works varies by condition, study design, and individual factors.
Evidence Score
High confidence
Category
Therapeutic area
Standard Dose
2-3x weekly
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Well characterized
Overview
Thymosin alpha-1 (Tα1) is a research-backed immune-modulating peptide. In plain terms, it’s intended to help tune immune activity rather than act like a generic ‘immune booster.’ In some countries it has been used as a prescription medicine (for example under the brand Zadaxin, depending on jurisdiction), and there are clinical trials across multiple indications. As with most immune-active compounds, the main safety framing is variability: some people tolerate it well, while others may experience side effects, and it’s important to use it under clinician guidance when it’s prescribed.
Mechanism of Action
Thymosin alpha-1 (Tα1) is a research-backed immune-modulating peptide. In plain terms, it’s intended to help tune immune activity rather than act like a generic ‘immune booster.’ In some countries it has been used as a prescription medicine (for example under the brand Zadaxin, depending on jurisdiction), and there are clinical trials across multiple indications. As with most immune-active compounds, the main safety framing is variability: some people tolerate it well, while others may experience side effects, and it’s important to use it under clinician guidance when it’s prescribed.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Immune modulation (reported in clinical research)
- Support for immune balance
- Studied in multiple human trials
Side Effects
- Generally reported as tolerable in many studies
- Injection-site reactions can occur
- Some people report flu-like or transient symptoms
Contraindications
- Pregnant or breastfeeding women (use only with clinician guidance)
- Individuals under 18 years old
- Those with known allergies or hypersensitivity to peptide components
Structure & Sequence
Verified structure
Thymosin Alpha-1
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- Ac-SDAAVDTSSEITTKDLKEKKEVEEEAEN (28aa)
- Chemical Formula
- C129H215N33O55
- CAS Number
- 62304-98-7
- Reconstituted pH
- 6.8
- InChIKey
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N
Stack & Route Context
Stacks with
- BPC-157
- LL-37
Administration
Subcutaneous
Research Status
Used in clinical contexts in some countries; studied across multiple human trials with a published safety/efficacy literature.
Approval Status
Approved
Sports Legal
Permitted
References
- 1View source
ClinicalTrials.gov: NCT04487444 (Thymalfasin/Thymosin-alpha-1) clinical study record
- 2View source
PMC review: Thymalfasin/Thymosin alpha-1 literature overview (comprehensive review)
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.