Tesamorelin
Research profile · How we handle evidence
FDA-approved specifically for reducing dangerous belly fat. One of the few peptides with full regulatory approval. Also may have brain-boosting benefits.
Evidence Score
High confidence
Category
Therapeutic area
Standard Dose
Once daily
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Well characterized
Overview
Tesamorelin is FDA-approved to melt belly fat. Specifically the dangerous visceral fat around your organs. It's legit medicine, not a research chemical. Bonus: studies show it may help your brain work better too.
Mechanism of Action
Tesamorelin is FDA-approved to melt belly fat. Specifically the dangerous visceral fat around your organs. It's legit medicine, not a research chemical. Bonus: studies show it may help your brain work better too.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- FDA-approved for belly fat
- Targets dangerous visceral fat
- Improves cholesterol
- May boost brain function
Side Effects
- Injection site reactions
- Possible water retention
- Joint pain
- Swelling in hands/feet
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
- Active cancer
- Uncontrolled diabetes
Structure & Sequence
Verified structure
Tesamorelin
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- (trans-3-hexenoyl)-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH2 (44aa)
- Molecular Weight
- 5,135.9 Da
- Chemical Formula
- C221H366N72O67S
- CAS Number
- 218949-48-5
- Reconstituted pH
- 4.5-7.4
- InChIKey
- QBEPNUQJQWDYKU-BMGKTWPMSA-N
Stack & Route Context
Stacks with
- Ipamorelin
- AOD-9604
Administration
Subcutaneous
Research Status
FDA approved (Egrifta brand).
Approval Status
Approved
Sports Legal
Restricted
References
- 1View source
Tesamorelin reduces visceral adipose tissue in HIV-infected patients
2010
- 2
Cognitive effects of tesamorelin in adults with cognitive impairment
2019
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.