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TB-500

Research profile · How we handle evidence

Thymosin Beta-4 fragment (TB-500). A synthetic version of a naturally occurring 43 amino acid peptide found in virtually every cell in your body. This peptide is all about systemic repair - it travels through your bloodstream fixing damage everywhere, not just at the injection site.

Evidence Score

55/100

Preclinical signal

Category

Healing & Recovery

Therapeutic area

Standard Dose

2-5mg

Loading: 2x weekly for 4-6 weeks, then 1x weekly

Half-life

~7 hr

Plasma elimination

Route

SC

Subcutaneous

Safety Tier

3

Limited data

Overview

TB-500 is like broadcasting a repair signal to your entire body at once. Unlike BPC-157 which works best locally where you inject it, TB-500 goes everywhere. Perfect when you have multiple injuries or want full-body recovery. It's the difference between sending a local contractor versus a system-wide repair crew.

Mechanism of Action

Binds to actin-binding proteins, promoting cell migration and tissue repair. Stimulates angiogenesis and reduces inflammation at injury sites throughout the body.

Sequesters G Actin Monomers To Promote Actin Polymerization For Cell MigrationDownregulates NF KB Pathway To Reduce Systemic Inflammatory Cytokine ProductionRecruits Endothelial Progenitor Cells To Injury Sites For RevascularizationModulates MMP Expression To Balance Tissue Remodeling And Scar Prevention

pH & Mixing

4.5

Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.

A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.

Benefits

  • Systemic (full-body) tissue repair - works everywhere
  • Improves flexibility and range of motion significantly
  • Reduces inflammation throughout the entire body
  • May support hair regrowth in some users
  • Cardioprotective properties - helps heart tissue

Side Effects

  • Generally well-tolerated by most people
  • Possible temporary fatigue during the loading phase
  • Rare head rush or lightheadedness after injection

Contraindications

  • Pregnant or breastfeeding women
  • Individuals under 18 years old
  • Those with known allergies to peptide components

Structure & Sequence

View 3D structure

Verified structure

TB-500

Sequence illustration backed by PubChem match.

Verified via PubChemMatched by casNumber
C212H350N56O78S4,963.55 DaCAS 77591-33-443 residues
Source: PubChemLookup: 77591-33-4InChIKey UGPMCIBIHRSCBV-XNBOLLIBSA-N
Amino Acid Sequence
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES (Thymosin Beta-4, 43aa)
Molecular Weight
4,963.55 Da
Chemical Formula
C212H350N56O78S
CAS Number
77591-33-4
Reconstituted pH
4.5
InChIKey
UGPMCIBIHRSCBV-XNBOLLIBSA-N

Stack & Route Context

Stacks with

  • BPC-157
  • GHK-Cu

Administration

Subcutaneous

Research Status

Well-studied peptide for tissue repair and regeneration. Multiple animal studies demonstrate efficacy in wound healing and tissue repair. Less human data than BPC-157 but strong preclinical evidence.

Approval Status

Preclinical

Sports Legal

Restricted

References

  1. 1

    Thymosin beta 4: a multi-functional regenerative peptide

    2012

    View source
  2. 2

    Thymosin beta4 promotes dermal healing

    1999

    View source
  3. 3

    TB4 promotes cardiac cell migration and survival

    2004

    View source

This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.

Research-driven insights.Evidence-based decisions.