Sermorelin
Research profile · How we handle evidence
A safer, more natural way to boost growth hormone. It gently stimulates your own GH production rather than flooding your body with synthetic hormones. Popular in anti-aging clinics.
Evidence Score
High confidence
Category
Therapeutic area
Standard Dose
Daily before bed
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Well characterized
Overview
Sermorelin is like a gentle nudge to your brain saying 'hey, make more growth hormone.' It's the natural approach, letting your body do the work. Doctors love it because it's safer for long-term use.
Mechanism of Action
Sermorelin is like a gentle nudge to your brain saying 'hey, make more growth hormone.' It's the natural approach, letting your body do the work. Doctors love it because it's safer for long-term use.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Natural GH stimulation
- Better body composition
- Improved sleep
- Faster recovery
- Keeps your pituitary healthy
Side Effects
- Injection site reactions
- Flushing
- Headache
- Dizziness
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
- Active cancer
- Uncontrolled diabetes
Structure & Sequence
Verified structure
Sermorelin
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2 (GHRH 1-29)
- Molecular Weight
- 3,357.9 Da
- Chemical Formula
- C149H246N44O42S
- CAS Number
- 86168-78-7
- Reconstituted pH
- 5.0-5.5
- InChIKey
- WGWPRVFKDLAUQJ-MITYVQBRSA-N
Stack & Route Context
Stacks with
- Ipamorelin
- GHRP-2
Administration
Subcutaneous
Research Status
Available through compounding pharmacies
Approval Status
Approved
Sports Legal
Restricted
References
- 1View source
Sermorelin therapy for adult growth hormone deficiency
2003
- 2View source
Long-term safety of sermorelin therapy
2005
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.