Semax
Research profile · How we handle evidence
Semax is a synthetic heptapeptide derived from a fragment of ACTH (adrenocorticotropic hormone). Developed in Russia and used as a prescription medicine there, it is studied for effects on learning and memory, and for neuroprotective signaling in the brain.
Evidence Score
High confidence
Category
Therapeutic area
Standard Dose
1-2x daily
Half-life
Plasma elimination
Route
Subcutaneous or Intranasal
Safety Tier
Well characterized
Overview
Semax is a prescription-style peptide nootropic (in Russia) that’s designed to support brain resilience rather than just “spiking” energy. It’s often used as a nasal spray, and many people report improved focus and mental clarity within about 30–60 minutes. The longer-term interest is neurotrophic signaling—especially BDNF—supporting neuroplasticity and protection in stress- or injury-related contexts. Use should be discussed with a clinician, and response varies person to person.
Mechanism of Action
Semax is a prescription-style peptide nootropic (in Russia) that’s designed to support brain resilience rather than just “spiking” energy. It’s often used as a nasal spray, and many people report improved focus and mental clarity within about 30–60 minutes. The longer-term interest is neurotrophic signaling—especially BDNF—supporting neuroplasticity and protection in stress- or injury-related contexts. Use should be discussed with a clinician, and response varies person to person.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Enhanced focus and concentration
- Support for learning and memory formation
- Neuroprotection signals under stress
- May increase BDNF (brain-derived neurotrophic factor)
- Mood/stress resilience support
- Generally reported as non-sedating
Side Effects
- Possible nasal irritation or dryness with intranasal use
- Mild headache in some people, often during early use
- Other side effects are reported rarely in the available literature
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
Structure & Sequence
Verified structure
Semax
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- MEHFPGP
- Molecular Weight
- 813.93 Da
- Chemical Formula
- C37H51N9O10S
- CAS Number
- 189691-05-2
- Reconstituted pH
- 5.4
- InChIKey
- AFEHBIGDWIGTEH-AQRCPPRCSA-N
Stack & Route Context
Stacks with
- Selank
- P21
- NA-Semax-Amidate
Administration
Subcutaneous or Intranasal
Research Status
Approved prescription medication in Russia since 2011
Approval Status
Approved
Sports Legal
Permitted
References
- 1View source
Semax, a synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations
1999
- 2View source
The peptide semax affects the expression of genes related to the immune and vascular systems
2013
- 3View source
Neuroprotective effect of Semax in conditions of global cerebral ischemia
1996
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.