Semaglutide
Research profile · How we handle evidence
The famous "Ozempic" weight loss drug that everyone's talking about. FDA-approved and incredibly effective - most people lose 15-20% of their body weight. Works by reducing appetite and slowing digestion. This is the real deal, not snake oil.
Evidence Score
High confidence
Category
Therapeutic area
Standard Dose
Once weekly injection
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Well characterized
Overview
This is the "Ozempic" everyone's talking about at parties. FDA-approved and people are legitimately losing 15-20% of their body weight. Works by making you feel full faster and killing cravings. Once a week injection. Game changer for some people, but not magic - you still gotta watch what you eat somewhat.
Mechanism of Action
GLP-1 receptor agonist that enhances insulin secretion, suppresses glucagon release, and slows gastric emptying for improved glycemic control and weight loss. Also acts on brain centers to reduce appetite.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Dramatic weight loss (15-20% body weight reduction)
- Kills food cravings effectively
- Better blood sugar control
- Heart health benefits
- FDA approved - not some sketchy research chemical
Side Effects
- Nausea (common at first - usually goes away)
- Vomiting
- Diarrhea
- Constipation
- Rare pancreas concerns
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
Structure & Sequence
Verified structure
Semaglutide
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- H-Aib-EGTFTSDVSSYLEGQAAK(PEG-PEG-γGlu-C18)-EFIAWLVRGRG
- Molecular Weight
- 4,113.58 Da
- Chemical Formula
- C187H291N45O59
- CAS Number
- 910463-68-2
- Reconstituted pH
- ~7.4
- InChIKey
- DLSWIYLPEUIQAV-CCUURXOWSA-N
Stack & Route Context
Stacks with
No entries listed.
Administration
Subcutaneous
Research Status
FDA-approved for type 2 diabetes and weight management. Well-established clinical efficacy with extensive safety data. One of the most studied weight loss medications ever.
Approval Status
Approved
Sports Legal
Permitted
References
- 1View source
STEP 1 Trial: Semaglutide for weight management
2021
- 2View source
Semaglutide and cardiovascular outcomes (SELECT trial)
2023
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.