Selank
Research profile · How we handle evidence
Selank is a synthetic heptapeptide originally derived from tuftsin, an immunomodulatory peptide. Developed and used in Russia alongside Semax, it is studied for anxiolytic (anti-anxiety) effects and for supporting cognitive performance under stress, with an emphasis on feeling calm without typical sedative impairment.
Evidence Score
High confidence
Category
Therapeutic area
Standard Dose
1-2x daily (nasal or subcutaneous)
Half-life
Plasma elimination
Route
Subcutaneous or Intranasal
Safety Tier
Well characterized
Overview
Selank is often described as a “calm without fog” peptide. It aims to reduce anxiety-related tension while helping you stay mentally clear and functional—so it’s commonly considered for high-stress days. Individual responses vary, and it’s best approached as a prescription-style option that should be discussed with a healthcare professional, especially if you take other medications.
Mechanism of Action
Selank is discussed in the literature as influencing GABAergic signaling and endogenous enkephalin systems. In combination with neuroplasticity-related pathways, this is proposed to produce anxiolytic effects while preserving cognitive functioning. Exact mechanisms in humans remain an active research area.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Anxiety support without prominent sedation (reported)
- May support attention and mental clarity under stress
- Potential benefits for learning and memory (studied)
- Balances signaling pathways involving GABA and related systems
- Immuno-related signaling effects reported in preclinical research
- Generally discussed as non-habit forming in the clinical literature
Side Effects
- Generally well-tolerated in reported studies
- Rare fatigue or transient tiredness (often mild and temporary, reported)
- Possible mild injection-site discomfort or nasal irritation depending on route
- If you experience unusual mood changes, allergic symptoms, or worsening anxiety, discontinue use and seek medical advice
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
Structure & Sequence
Verified structure
Selank
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- TKPRPGP
- Molecular Weight
- 751.85 Da
- Chemical Formula
- C33H57N11O9
- CAS Number
- 127154-85-9
- Reconstituted pH
- 11.7
- InChIKey
- JTDTXGMXNXBGBZ-YVHUGQOKSA-N
Stack & Route Context
Stacks with
- Semax
- BPC-157
Administration
Subcutaneous or Intranasal
Research Status
Approved in Russia as a prescription anxiolytic medication, with multiple clinical reports and ongoing research.
Approval Status
Approved
Sports Legal
Permitted
References
- 1View source
Selank: A novel peptide anxiolytic
2008
- 2View source
Comparative anxiolytic activity of selank and phenazepam
2009
- 3View source
Selank increases IL-6 gene expression in rat hippocampus
2012
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.