PTD-DBM
Research profile · How we handle evidence
PTD-DBM is a fusion peptide combining a Protein Transduction Domain (PTD), which carries the peptide across the cell membrane, with a Dishevelled-Binding Motif (DBM). Inside the cell, the DBM segment stabilizes Dishevelled (DVL), a key relay protein in Wnt signaling, which in turn activates the Wnt/beta-catenin pathway. Wnt/beta-catenin signaling is a central driver of hair-follicle stem-cell activation and cutaneous wound repair, which is why PTD-DBM is studied mainly in hair-growth and skin-regeneration research rather than in any cancer or p53 context.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
Varies by study protocol
Half-life
Plasma elimination
Route
Topical or Subcutaneous
Safety Tier
Limited data
Overview
PTD-DBM is a lab peptide researched for waking up hair follicles and speeding wound healing by turning on a cell-signaling pathway (Wnt/beta-catenin) that normally goes quiet in resting follicles and damaged skin.
Mechanism of Action
PTD-DBM is a lab peptide researched for waking up hair follicles and speeding wound healing by turning on a cell-signaling pathway (Wnt/beta-catenin) that normally goes quiet in resting follicles and damaged skin.
Benefits
- Studied for activation of Wnt/beta-catenin signaling in hair follicles
- Studied for supporting cutaneous wound-repair signaling
Side Effects
- Human safety data not established
- Long-term effects of sustained Wnt-pathway activation are not characterized
Contraindications
- No established human safety profile
- Not studied in pregnancy or in people with active or prior malignancy, given Wnt pathway's role in some cancers
- Avoid combining with other experimental Wnt-pathway modulators pending more data
Structure & Sequence
Verified structure
PTD-DBM
No public sequence, formula, or exact registry structure is available for this record.
No trustworthy illustration yet
This entry is missing a public exact structure, sequence, or usable formula. The verification record is still stored so it remains visible in the audit trail.
Stack & Route Context
Stacks with
No entries listed.
Administration
Topical or Subcutaneous
Research Status
Preclinical / early research
Approval Status
Preclinical
Sports Legal
Restricted
References
- 1
Dishevelled-binding fusion peptides and Wnt/beta-catenin activation in hair follicle regeneration
2016
- 2
Protein transduction domain-linked Wnt agonist peptides in cutaneous wound repair models
2018
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.