PEG-MGF
Research profile · How we handle evidence
PEG-MGF is a polyethylene-glycol–modified form of MGF (mechano growth factor). The PEG modification is used to extend how long the molecule stays active in the body compared with native MGF, which is short-lived. This is why PEG-MGF is commonly discussed in research settings for less frequent dosing schedules.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
2-3x weekly
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Limited data
Overview
MGF is a brief, locally acting signaling peptide fragment associated with exercise/mechanical stress responses. PEG-MGF is the longer-circulating, PEGylated variant meant to smooth out that short half-life so the signal lasts longer.
Mechanism of Action
MGF is a brief, locally acting signaling peptide fragment associated with exercise/mechanical stress responses. PEG-MGF is the longer-circulating, PEGylated variant meant to smooth out that short half-life so the signal lasts longer.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Extended half-life
- Sustained muscle growth
- Less frequent dosing
- Enhanced recovery
Side Effects
- Injection site reactions
- Potential water retention
Contraindications
- Cancer
- Pregnancy
- Minors
Structure & Sequence
Verified structure
PEG-MGF
Illustration uses the catalog amino acid sequence because no exact external registry match was confirmed.
- Amino Acid Sequence
- YQPPSTNKNTKSQRRKGSTFEEHK (MGF core, 24aa, PEGylated)
- Molecular Weight
- 2,867 Da (core peptide)
- Chemical Formula
- C121H200N42O39 (core peptide)
- CAS Number
- 108174-48-7
- Reconstituted pH
- 10.8
Stack & Route Context
Stacks with
- IGF-1 LR3
- HGH
Administration
Subcutaneous
Research Status
Research peptide for muscle growth
Approval Status
Preclinical
Sports Legal
Restricted
References
- 1View source
MGF (Mechano Growth Factor) — induced muscle stem cell activity (review/overview) (Springer article landing)
2017
- 2View source
PEG-MGF overview (research peptide background) (reference page)
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.