PE 22-28
Research profile · How we handle evidence
Peptide fragment that enhances cognitive function and provides neuroprotection.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
Daily
Half-life
Plasma elimination
Route
Subcutaneous or Intranasal
Safety Tier
Limited data
Overview
PE 22-28 is a short peptide fragment derived from a larger neuroprotective protein, and it's being explored as a cognitive enhancer with a focus on neuroprotection rather than stimulation. Unlike stimulant-based nootropics, PE 22-28 works more quietly, it supports neuron survival, helps with synaptic plasticity, and may protect against oxidative stress in the brain. It's in the same general category as Semax and Selank but with less research behind it, so it's more speculative. Most users take it intranasally for direct nose-to-brain delivery, and it's typically stacked with other cognitive peptides rather than used solo. If you're building a neuroprotective protocol, this is a supporting player, not the main act.
Mechanism of Action
PE 22-28 is a short peptide fragment derived from a larger neuroprotective protein, and it's being explored as a cognitive enhancer with a focus on neuroprotection rather than stimulation. Unlike stimulant-based nootropics, PE 22-28 works more quietly, it supports neuron survival, helps with synaptic plasticity, and may protect against oxidative stress in the brain. It's in the same general category as Semax and Selank but with less research behind it, so it's more speculative. Most users take it intranasally for direct nose-to-brain delivery, and it's typically stacked with other cognitive peptides rather than used solo. If you're building a neuroprotective protocol, this is a supporting player, not the main act.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Cognitive enhancement
- Neuroprotection
- Memory improvement
- Focus enhancement
Side Effects
- Generally well-tolerated
Contraindications
- Pregnant or breastfeeding women
Structure & Sequence
Verified structure
PE 22-28
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- GVSWGLR
- Molecular Weight
- 773.89 Da
- Chemical Formula
- C35H55N11O9
- CAS Number
- 1801959-12-5
- Reconstituted pH
- 10.6
- InChIKey
- CMNBQRXBBJQIOA-YIHYGEMESA-N
Stack & Route Context
Stacks with
- Semax
- Selank
Administration
Subcutaneous or Intranasal
Research Status
Research peptide for cognitive enhancement
Approval Status
Preclinical
Sports Legal
Permitted
References
- 1View source
PE 22-28 — sequence and TREK-1 inhibitory fragment (overview)
2024
- 2View source
Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity
2017
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.