NA-Semax Amidate
Research profile · How we handle evidence
NA-Semax amidate is a modified form of Semax chemistry (acetylated and C-terminal amidated) that is studied/referenced in research and peptide chemistry contexts.
Evidence Score
Preliminary signal
Category
Therapeutic area
Standard Dose
1-2x daily
Half-life
Plasma elimination
Route
Intranasal
Safety Tier
Limited data
Overview
NA-Semax amidate is an analog built from the Semax peptide backbone using common peptide-stability modifications (N-acetylation and C-terminal amidation). In educational terms, that kind of chemistry is often explored to see whether a compound stays intact longer or shows different pharmacology than the original. Because it is typically sold and discussed as a research chemical, evidence for consistent clinical outcomes can be limited. If you’re exploring any neuroactive compound, treat this as information for research library use only: focus on known risks (for example, overstimulation or intolerance), start conservatively only under qualified guidance, and stop if you feel unwell.
Mechanism of Action
NA-Semax amidate is an analog built from the Semax peptide backbone using common peptide-stability modifications (N-acetylation and C-terminal amidation). In educational terms, that kind of chemistry is often explored to see whether a compound stays intact longer or shows different pharmacology than the original. Because it is typically sold and discussed as a research chemical, evidence for consistent clinical outcomes can be limited. If you’re exploring any neuroactive compound, treat this as information for research library use only: focus on known risks (for example, overstimulation or intolerance), start conservatively only under qualified guidance, and stop if you feel unwell.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Investigated as a Semax analog with altered stability
- Potential focus/mood effects are discussed in community reports (not a substitute for clinical proof)
Side Effects
- Possible nasal irritation
- Possible overstimulation in sensitive individuals
Contraindications
- Pregnant or breastfeeding women (avoid unless clinician-guided)
- Individuals under 18 years old
- Those with known allergies or peptide hypersensitivity
Structure & Sequence
Verified structure
NA-Semax Amidate
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 (NA-Semax Amidate)
- Molecular Weight
- 854.97 Da
- Chemical Formula
- C39H54N10O10S
- Reconstituted pH
- 5.3
- InChIKey
- QQOAKFVAEDCKGY-HPMAGDRPSA-N
Stack & Route Context
Stacks with
- Selank
- P21
Administration
Intranasal
Research Status
Research compound/analog; evidence base can be limited and varies by source.
Approval Status
Research
Sports Legal
Permitted
References
- 1View source
PubChem: N-acetyl semax amidate (CID entry / starting point for structure & properties)
- 2View source
MedChemExpress: N-Acetyl Semax Amidate (reference page; chemistry/identity starting point)
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.