N-Acetyl Semax Amidate
Research profile · How we handle evidence
A modified Semax (ACTH(4-10) analog) where the N-terminus is acetylated and the C-terminus is amidated, which can change stability and how the peptide behaves in biological systems.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
1-2x daily
Half-life
Plasma elimination
Route
Intranasal
Safety Tier
Limited data
Overview
N-Acetyl Semax Amidate is a chemically modified version of Semax. The acetylation and amidation are meant to improve peptide stability and alter how the molecule behaves in the body. In plain terms, people who experiment with Semax-family peptides often report a faster, shorter-acting effect and then look for the version that feels more consistent. Because direct human data for this exact compound is limited, treat any 'working memory' or 'focus' expectations as anecdotal. If you try it, start conservatively, pay attention to sleep and heart rate, and stop if you feel unwell. If you have a medical condition or take medications, it’s smart to check with a clinician first.
Mechanism of Action
N-Acetyl Semax Amidate is a chemically modified version of Semax. The acetylation and amidation are meant to improve peptide stability and alter how the molecule behaves in the body. In plain terms, people who experiment with Semax-family peptides often report a faster, shorter-acting effect and then look for the version that feels more consistent. Because direct human data for this exact compound is limited, treat any 'working memory' or 'focus' expectations as anecdotal. If you try it, start conservatively, pay attention to sleep and heart rate, and stop if you feel unwell. If you have a medical condition or take medications, it’s smart to check with a clinician first.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Enhanced cognitive function
- Better memory
- Improved focus
- Longer duration
- Better bioavailability
Side Effects
- Rare
- Possible overstimulation
- Nasal irritation
Contraindications
- Pregnant or breastfeeding women
Structure & Sequence
Verified structure
N-Acetyl Semax Amidate
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 (NA-Semax Amidate)
- Molecular Weight
- 854.97 Da
- Chemical Formula
- C39H54N10O10S
- CAS Number
- N/A
- Reconstituted pH
- 5.3
- InChIKey
- QQOAKFVAEDCKGY-HPMAGDRPSA-N
Stack & Route Context
Stacks with
- Selank
- P21
Administration
Intranasal
Research Status
Research chemical. Enhanced Semax.
Approval Status
Preclinical
Sports Legal
Permitted
References
- 1View source
N-Acetyl semax amidate (PubChem compound entry)
- 2View source
Influence of the N-terminus acetylation of Semax on copper/zinc coordination and biological properties
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.