MGF (Mechano Growth Factor)
Research profile · How we handle evidence
MGF (mechano growth factor) is an IGF-1 splice variant (often described as IGF-1Ec/E-peptide) associated with the cellular response to mechanical stress. In research models, it’s studied for effects on muscle stem (satellite) cell activation and repair signaling. Evidence is mostly preclinical.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
Post-workout, 2-3x weekly
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Limited data
Overview
MGF is a short-lived peptide fragment produced from the IGF-1 gene via alternative splicing. In muscle, it’s discussed as part of the signaling chain that helps satellite cells respond after training or tissue stress.
Mechanism of Action
MGF is a short-lived peptide fragment produced from the IGF-1 gene via alternative splicing. In muscle, it’s discussed as part of the signaling chain that helps satellite cells respond after training or tissue stress.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Satellite cell activation
- Muscle repair
- Exercise-induced growth
- Local muscle effects
Side Effects
- Injection site reactions
- Potential muscle cramps
Contraindications
- Cancer
- Pregnancy
- Minors
Structure & Sequence
Verified structure
MGF (Mechano Growth Factor)
Illustration uses the catalog amino acid sequence because no exact external registry match was confirmed.
- Amino Acid Sequence
- YQPPSTNKNTKSQRRKGSTFEEHK
- Molecular Weight
- 2,888.16 Da
- Chemical Formula
- C121H200N42O39
- CAS Number
- N/A
- Reconstituted pH
- 10.8
Stack & Route Context
Stacks with
- IGF-1 LR3
- HGH
Administration
Subcutaneous
Research Status
Research peptide for muscle growth
Approval Status
Preclinical
Sports Legal
Restricted
References
- 1View source
Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain
2017
- 2View source
MGF (IGF-1 splice variant) described as a local signaling peptide activating satellite cells (Springer/overview)
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.