Matrixyl (Palmitoyl Pentapeptide-4)
Research profile · How we handle evidence
Matrixyl is the trade name for Palmitoyl Pentapeptide-4 (Pal-KTTKS), a lipidated fragment of type I procollagen developed by Sederma and launched in 2000 as a cosmetic anti-aging active. It signals fibroblasts as a matrikine, encouraging extracellular-matrix production.
Evidence Score
Preliminary signal
Category
Therapeutic area
Standard Dose
1-2x daily, applied to skin
Half-life
Plasma elimination
Route
Topical
Safety Tier
Limited data
Overview
Matrixyl is a signal peptide attached to a fatty acid so it can penetrate skin. The idea is that this fragment mimics a piece of collagen breakdown, which fibroblasts read as a cue to rebuild more collagen and elastin - a common active in over-the-counter anti-aging serums and creams.
Mechanism of Action
Matrixyl is a signal peptide attached to a fatty acid so it can penetrate skin. The idea is that this fragment mimics a piece of collagen breakdown, which fibroblasts read as a cue to rebuild more collagen and elastin - a common active in over-the-counter anti-aging serums and creams.
Benefits
- Marketed to support visible collagen and elastin production in skin
- One of the most widely used matrikine peptides in over-the-counter skincare
- Often combined with Palmitoyl Tetrapeptide-7 as 'Matrixyl 3000'
Side Effects
- Mild skin irritation possible in sensitive individuals
- No systemic effects expected at cosmetic topical concentrations
Contraindications
- Known sensitivity to the ingredient
- Not for injection - topical cosmetic use only
Structure & Sequence
Verified structure
Matrixyl (Palmitoyl Pentapeptide-4)
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- Pal-Lys-Thr-Thr-Lys-Ser-OH (Pal-KTTKS)
- Molecular Weight
- 802.05 Da
- Chemical Formula
- C39H75N7O10
- CAS Number
- 214047-00-4
- InChIKey
- WSGCRSMLXFHGRM-DEVHWETNSA-N
Stack & Route Context
Stacks with
No entries listed.
Administration
Topical
Research Status
Widely used since 2000 with in-vitro fibroblast studies and manufacturer/industry clinical testing supporting topical collagen-signaling claims; independent, large-scale human trials are limited, as is typical for cosmetic actives.
Approval Status
Cosmetic Use
Sports Legal
Permitted
References
- 1View source
Palmitoyl Pentapeptide-4 - PubChem CID 9897237
2005
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.