KPV
Research profile · How we handle evidence
KPV is a short tripeptide (Lys–Pro–Val) derived from the alpha-MSH sequence. It’s studied for anti-inflammatory behavior and shows up in gut and skin research discussions, but it is not an approved treatment.
Evidence Score
Preliminary signal
Category
Therapeutic area
Standard Dose
1-2x daily
Half-life
Plasma elimination
Route
Subcutaneous or Oral
Safety Tier
Limited data
Overview
KPV is only three amino acids long. In research settings it’s described as modulating parts of immune and inflammatory signaling, and some studies look at how it may act through pathways related to melanocortin biology. People bring it up when they’re looking at persistent inflammation patterns (like gut-related inflammation or skin inflammation). Still, the human evidence base is limited, so treat it as investigational.
Mechanism of Action
KPV is only three amino acids long. In research settings it’s described as modulating parts of immune and inflammatory signaling, and some studies look at how it may act through pathways related to melanocortin biology. People bring it up when they’re looking at persistent inflammation patterns (like gut-related inflammation or skin inflammation). Still, the human evidence base is limited, so treat it as investigational.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Research interest in lowering inflammatory signaling
- Often discussed for gut inflammation support
- Often discussed for skin irritation/inflammation support
- May affect inflammation-related signaling rather than acting as a blanket “shutoff”
Side Effects
- Generally reported as well-tolerated
- Possible mild gastrointestinal discomfort
- Topical or injection use may cause local irritation
- Because it’s immune-active, uncommon sensitivity or intolerance is possible
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
- Avoid if you have an active serious infection or are under active immune-modulating medical care unless supervised
Structure & Sequence
Verified structure
KPV
Illustration uses the catalog amino acid sequence because no exact external registry match was confirmed.
- Amino Acid Sequence
- Lys-Pro-Val (KPV)
- Molecular Weight
- 342.43 Da
- Chemical Formula
- C16H30N4O4
- CAS Number
- N/A
- Reconstituted pH
- 9.7
Stack & Route Context
Stacks with
- BPC-157
Administration
Subcutaneous or Oral
Research Status
Research peptide (investigational). Often used in supplement/biohacking contexts.
Approval Status
Research
Sports Legal
Permitted
References
No references listed.
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.