Kisspeptin
Research profile · How we handle evidence
Kisspeptin is a naturally occurring neuropeptide encoded by the KISS1 gene that acts as a master regulator of the reproductive hormone cascade. It stimulates GnRH (gonadotropin-releasing hormone) release, which in turn drives LH and FSH secretion, ultimately stimulating testosterone and estrogen production. It is being researched for fertility treatment, hypogonadism, and as a male fertility-preserving PCT alternative.
Evidence Score
Moderate confidence
Category
Therapeutic area
Standard Dose
Daily to twice daily (short half-life)
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Monitor closely
Overview
Kisspeptin sits at the very top of your body's hormone pyramid, it's the brain's master switch that tells your pituitary to release LH and FSH, which then signal your testes or ovaries to produce testosterone and estrogen. That's why it's generating so much excitement as a potential alternative to traditional PCT: instead of blocking estrogen receptors with a SERM to trick your body into making more testosterone, kisspeptin just turns the natural system back on from the top. It's currently in Phase 2-3 clinical trials for hypogonadism and fertility, so the science is more advanced than most research peptides. The practical challenge is its very short half-life (around 30 minutes), which often means multiple daily injections or a pump. If you're looking to restore natural hormone production without the emotional rollercoaster of Clomid, this is absolutely one to keep an eye on.
Mechanism of Action
Kisspeptin sits at the very top of your body's hormone pyramid, it's the brain's master switch that tells your pituitary to release LH and FSH, which then signal your testes or ovaries to produce testosterone and estrogen. That's why it's generating so much excitement as a potential alternative to traditional PCT: instead of blocking estrogen receptors with a SERM to trick your body into making more testosterone, kisspeptin just turns the natural system back on from the top. It's currently in Phase 2-3 clinical trials for hypogonadism and fertility, so the science is more advanced than most research peptides. The practical challenge is its very short half-life (around 30 minutes), which often means multiple daily injections or a pump. If you're looking to restore natural hormone production without the emotional rollercoaster of Clomid, this is absolutely one to keep an eye on.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Stimulates natural testosterone production from the top of the HPG axis
- Preserves testicular function (unlike SERM-based PCT)
- May improve fertility outcomes
- No estrogen blockade side effects
- Being researched for hypogonadism treatment
- Potential for both male and female fertility applications
Side Effects
- Generally well-tolerated in clinical trials
- Potential desensitization with continuous high-dose administration
- Injection site reactions
- Short half-life requires frequent dosing
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
Structure & Sequence
Verified structure
Kisspeptin
Illustration uses the catalog amino acid sequence because no exact external registry match was confirmed.
- Amino Acid Sequence
- YNWNSFGLRF (kisspeptin-10)
- Molecular Weight
- 1,302.5 Da (kisspeptin-10)
- Chemical Formula
- C63H83N17O14 (kisspeptin-10)
- CAS Number
- 370950-96-2
- Reconstituted pH
- 9.3
Stack & Route Context
Stacks with
- HCG
- Clomid/Enclomiphene (but may be alternative to)
- Testosterone (TRT)
Administration
Subcutaneous
Research Status
Active Phase 2-3 clinical trials for hypogonadism and fertility. Not yet FDA approved. Research peptide.
Approval Status
Phase2
Sports Legal
Restricted
References
- 1View source
Kisspeptin for treating hypogonadism
2015
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.