Humanin
Research profile · How we handle evidence
Humanin is a mitochondrial-derived peptide that shows up in research on how cells handle stress. It was first described in the early 2000s and is often discussed in the context of Alzheimer’s disease biology and other age-related changes.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
Daily or 3x weekly
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Limited data
Overview
Humanin is a small peptide that researchers study as part of the cell’s response to mitochondrial stress. In lab and animal work, it’s linked to ways cells resist damage under conditions like oxidative stress. Human evidence is still limited, so it’s best treated as an active research topic rather than an established effect in people.
Mechanism of Action
Humanin is a small peptide that researchers study as part of the cell’s response to mitochondrial stress. In lab and animal work, it’s linked to ways cells resist damage under conditions like oxidative stress. Human evidence is still limited, so it’s best treated as an active research topic rather than an established effect in people.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Cell-stress signaling research
- Neuroprotection in preclinical models
- Research links to Alzheimer’s biology
- Mitochondrial response signaling
Side Effects
- Human safety data is limited
- If used as an injectable, possible injection-site irritation
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
Structure & Sequence
Verified structure
Humanin
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- MAPRGFSCLLLLTSEIDLPVKRRA
- Molecular Weight
- 2,687.3 Da
- Chemical Formula
- C119H204N34O32S2
- CAS Number
- 343927-47-7
- Reconstituted pH
- 9.8
- InChIKey
- DPEUWKZJZIPZKE-OFANTOPUSA-N
Stack & Route Context
Stacks with
- MOTS-c
- SS-31
Administration
Subcutaneous
Research Status
Research peptide. Active research area.
Approval Status
Preclinical
Sports Legal
Permitted
References
No references listed.
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.