Hexarelin
Research profile · How we handle evidence
The most powerful single-dose GH releaser, but your body builds tolerance quickly. Also has unique heart-protective benefits not found in other GH peptides.
Evidence Score
Moderate confidence
Category
Therapeutic area
Standard Dose
1-2x daily
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Monitor closely
Overview
Hexarelin is the nuclear option for growth hormone release, it produces the biggest acute GH spike of any secretagogue, period. The catch is that your body desensitizes to it within weeks, so you absolutely cannot run it indefinitely like you can with ipamorelin or MK-677. The really interesting part is its unique cardioprotective effect: hexarelin binds to a special receptor on heart cells (CD36) that other GHRPs don't touch, which is why researchers have studied it for improving ejection fraction in heart failure patients. Most experienced users cycle it for 4-6 weeks max, then switch to a gentler GH peptide. One practical note: it tends to spike cortisol and prolactin more than alternatives, so if you're sensitive to those, start with a lower dose and see how you feel.
Mechanism of Action
Hexarelin is the nuclear option for growth hormone release, it produces the biggest acute GH spike of any secretagogue, period. The catch is that your body desensitizes to it within weeks, so you absolutely cannot run it indefinitely like you can with ipamorelin or MK-677. The really interesting part is its unique cardioprotective effect: hexarelin binds to a special receptor on heart cells (CD36) that other GHRPs don't touch, which is why researchers have studied it for improving ejection fraction in heart failure patients. Most experienced users cycle it for 4-6 weeks max, then switch to a gentler GH peptide. One practical note: it tends to spike cortisol and prolactin more than alternatives, so if you're sensitive to those, start with a lower dose and see how you feel.
Benefits
- Strongest immediate GH release
- Heart-protective effects
- Improved heart function
- Enhanced recovery
Side Effects
- Builds tolerance quickly
- Raises cortisol
- Increases prolactin
- Water retention
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
- Active cancer
- Uncontrolled diabetes
Structure & Sequence
Verified structure
Hexarelin
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
- Molecular Weight
- 887.04 Da
- Chemical Formula
- C47H58N12O6
- InChIKey
- RVWNMGKSNGWLOL-GIIHNPQRSA-N
Stack & Route Context
Stacks with
- CJC-1295
Administration
Subcutaneous
Research Status
Studied for heart health
Approval Status
Phase2
Sports Legal
Restricted
References
- 1View source
Cardioprotective effects of hexarelin in GH-deficient adults
2000
- 2
Hexarelin improves cardiac performance in GH-deficient rats
1999
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.