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GHK-Cu

Research profile · How we handle evidence

GHK-Cu is a naturally occurring copper-binding tripeptide made in the body. Levels tend to decline with age, which is one reason it is studied for skin appearance changes, support of wound repair, and hair follicle health. In research and clinical settings, GHK-Cu is often discussed as a modulator of pathways involved in extracellular-matrix repair and oxidative stress protection.

Evidence Score

73/100

Moderate confidence

Category

Anti-Aging & Healing

Therapeutic area

Standard Dose

0.5-2% topical or 1-3mg injectable

1-2x daily

Half-life

~3 hr

Plasma elimination

Route

SC / TD

Subcutaneous or Transdermal

Safety Tier

2

Monitor closely

Overview

GHK-Cu is a copper-binding signal peptide studied for skin-support and repair. Because endogenous levels can decline with age, supplementation is marketed to support processes involved in extracellular-matrix maintenance. In practice, responses vary by product, route (topical vs. injection), and individual factors—so it’s best approached as supportive care, not a guaranteed anti-aging treatment.

Mechanism of Action

GHK-Cu is thought to interact with copper-dependent signaling and influence pathways involved in extracellular-matrix turnover, wound-repair signaling, and protection against oxidative stress. Depending on formulation and route, it may affect fibroblast function and downstream gene-expression patterns related to matrix maintenance.

Copper Peptide Complex That Activates Matrix Metalloproteinases For Tissue RemodelingStimulates Collagen I, Collagen IV, And Elastin Synthesis In FibroblastsFunctions As A SOD Mimetic, Reducing Superoxide Radical DamageUpregulates Decorin And Glycosaminoglycan Production For Extracellular Matrix Repair

Benefits

  • Boosts collagen production for younger-looking skin
  • Reduces wrinkles and fine lines noticeably
  • Speeds up wound healing significantly
  • Stimulates hair growth and thickness
  • Powerful antioxidant protection for cells

Side Effects

  • Generally well-tolerated in reported cosmetic contexts
  • Injection products may cause temporary redness, swelling, or irritation at the site
  • Topical products can sometimes cause dryness, irritation, or a burning sensation
  • Stop use and seek medical advice if you develop persistent symptoms, rash, or signs of allergy

Contraindications

  • Pregnant or breastfeeding women
  • Individuals under 18 years old
  • Those with known allergies to peptide components

Structure & Sequence

Verified structure

GHK-Cu

Illustration uses the catalog amino acid sequence because no exact external registry match was confirmed.

Sequence-backed
C14H24CuN6O4404.96 DaCAS 49557-75-73 residues
Amino Acid Sequence
GHK
Molecular Weight
404.96 Da
Chemical Formula
C14H24CuN6O4
CAS Number
49557-75-7

Stack & Route Context

Stacks with

  • BPC-157
  • TB-500
  • Epithalon

Administration

Subcutaneous or Transdermal

Research Status

FDA-approved for wound healing. Well-established in clinical use for tissue regeneration and anti-aging applications. One of the most proven peptides for cosmetic benefits.

Approval Status

Clinical

Sports Legal

Permitted

References

  1. 1

    GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration

    2015

    View source
  2. 2

    The human tripeptide GHK-Cu in prevention of oxidative stress

    2012

    View source
  3. 3

    GHK and DNA: resetting the human genome to health

    2014

    View source

This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.

Research-driven insights.Evidence-based decisions.