Epitalon (Epithalon)
Research profile · How we handle evidence
A tetrapeptide that activates telomerase, the enzyme that lengthens telomeres (the 'caps' on your DNA that shorten with age). Developed by Russian scientist Vladimir Khavinson for anti-aging.
Evidence Score
Preliminary signal
Category
Therapeutic area
Standard Dose
Daily for 10-20 days
Half-life
Plasma elimination
Route
Subcutaneous or Intranasal
Safety Tier
Limited data
Overview
Your DNA has 'caps' called telomeres that get shorter as you age. When they get too short, cells die. Epitalon tells your body to make telomerase, which rebuilds these caps. It's like turning back your cellular clock.
Mechanism of Action
Epitalon activates telomerase and regulates pineal function, while TA-65 only activates telomerase without the circadian component. Unlike NAD+ or NMN, which work through cellular energy and sirtuins, epitalon targets the aging clock directly at the chromosomal level. Thymalin is its immune-focused cousin from the same Russian research group.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Activates telomerase enzyme
- May extend cellular lifespan
- Improves sleep quality
- Regulates melatonin production
- Potential anti-aging effects
Side Effects
- Minimal side effects reported
- Generally well-tolerated
- Rare injection site reactions
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
Structure & Sequence
Verified structure
Epitalon (Epithalon)
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- Ala-Glu-Asp-Gly (AEDG)
- Molecular Weight
- 390.35 Da
- Chemical Formula
- C14H22N4O9
- Reconstituted pH
- 7.2
- InChIKey
- HGHOBRRUMWJWCU-FXQIFTODSA-N
Stack & Route Context
Stacks with
- Pinealon
- GHK-Cu
- Thymosin Alpha-1
Administration
Subcutaneous or Intranasal
Research Status
Part of Russian bioregulator research. Not FDA approved.
Approval Status
Research
Sports Legal
Permitted
References
- 1View source
Peptide bioregulator Epithalon activates telomerase
2003
- 2
Effects of Epithalon on age-related changes
2007
- 3
Khavinson peptide bioregulation research
2010
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.