DSIP (Delta Sleep-Inducing Peptide)
Research profile · How we handle evidence
Delta Sleep-Inducing Peptide (DSIP). A naturally occurring neuropeptide originally pulled from rabbit brain back in 1977. Found in brain, pituitary, adrenal glands, and blood plasma. As the name suggests, it promotes slow-wave (delta) sleep - the deep restorative stuff. Also reduces stress hormones and has been researched for insomnia, pain management, and alcohol withdrawal.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
Once daily (at bedtime)
Half-life
Plasma elimination
Route
Subcutaneous or Intravenous
Safety Tier
Limited data
Overview
DSIP is your body's natural sleep signal. It promotes deep delta sleep where most physical repair happens. Lowers cortisol and has mild pain-relieving properties. Used by researchers and biohackers for insomnia, stress, and improving sleep quality. Some report better mood and less anxiety. Not a sedative - you'll wake up feeling rested, not groggy.
Mechanism of Action
DSIP is your body's natural sleep signal. It promotes deep delta sleep where most physical repair happens. Lowers cortisol and has mild pain-relieving properties. Used by researchers and biohackers for insomnia, stress, and improving sleep quality. Some report better mood and less anxiety. Not a sedative - you'll wake up feeling rested, not groggy.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Promotes deep, restorative delta wave sleep
- Reduces cortisol and stress hormones
- Mild analgesic (pain-relieving) properties
- May help with alcohol withdrawal symptoms
- Non-sedating - improves sleep quality without morning grogginess
- Potentially anti-tumor properties (limited evidence)
Side Effects
- Generally well-tolerated
- Mild dizziness in some users
- Headache
- Very short half-life limits duration of action
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
Structure & Sequence
Verified structure
DSIP (Delta Sleep-Inducing Peptide)
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- WAGGDASGE
- Molecular Weight
- 848.9 Da
- Chemical Formula
- C35H48N10O15
- Reconstituted pH
- 3.6
- InChIKey
- ZRZROXNBKJAOKB-GFVHOAGBSA-N
Stack & Route Context
Stacks with
- Epithalon
- Selank
- Thymosin Alpha-1
Administration
Subcutaneous or Intravenous
Research Status
Limited human clinical research. Russian peptide with more Soviet-era research than Western trials. Research chemical with interesting potential.
Approval Status
Preclinical
Sports Legal
Permitted
References
- 1
Delta sleep-inducing peptide and sleep regulation
1984
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.