CJC-1295 DAC
Research profile · How we handle evidence
A long-lasting growth hormone booster that keeps your GH levels elevated for days. Often combined with Ipamorelin for what many consider the holy grail anti-aging stack. The DAC version is what makes it last - without it, you're looking at a 30-minute half-life like regular GHRH.
Evidence Score
Moderate confidence
Category
Therapeutic area
Standard Dose
Once weekly or twice weekly
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Monitor closely
Overview
CJC-1295 DAC is like a slow-release GH booster that keeps working for nearly a full week. The DAC (Drug Affinity Complex) binds to your blood's albumin, protecting the peptide from rapid breakdown, so one injection keeps growth hormone elevated for 6-8 days. This makes it incredibly convenient, just 1-2 injections per week instead of daily pinning. It's most commonly stacked with Ipamorelin for the classic anti-aging and body recomposition protocol that clinics love. Start with 1mg twice weekly and watch for water retention or carpal tunnel symptoms as signs you need to dial back. Don't run it for more than 12-24 weeks without a break to avoid GH axis desensitization.
Mechanism of Action
CJC-1295 DAC is like a slow-release GH booster that keeps working for nearly a full week. The DAC (Drug Affinity Complex) binds to your blood's albumin, protecting the peptide from rapid breakdown, so one injection keeps growth hormone elevated for 6-8 days. This makes it incredibly convenient, just 1-2 injections per week instead of daily pinning. It's most commonly stacked with Ipamorelin for the classic anti-aging and body recomposition protocol that clinics love. Start with 1mg twice weekly and watch for water retention or carpal tunnel symptoms as signs you need to dial back. Don't run it for more than 12-24 weeks without a break to avoid GH axis desensitization.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Long-acting - once or twice weekly dosing
- Sustained growth hormone elevation
- Increased IGF-1 production
- Improved body composition and fat loss
- Enhanced recovery and sleep quality
- Synergizes excellently with GHRP peptides
Side Effects
- Water retention at higher doses
- Carpal tunnel syndrome (from IGF-1 elevation)
- Numbness/tingling in extremities
- Increased hunger
- Fatigue
- Potential GH desensitization with long-term use
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
- Active cancer
- Uncontrolled diabetes
Structure & Sequence
Verified structure
CJC-1295 DAC
Illustration uses the catalog amino acid sequence because no exact external registry match was confirmed.
- Amino Acid Sequence
- Y-D-Ala-DAIFTQSYRKVLGQLSARKLLQDILSR-NH2 (30aa, GHRH 1-29 analog with DAC moiety)
- Molecular Weight
- 3,367.95 Da
- Chemical Formula
- C152H252N44O42
- Reconstituted pH
- 10.6
Stack & Route Context
Stacks with
- Ipamorelin
- GHRP-6
- GHRP-2
- BPC-157
Administration
Subcutaneous
Research Status
Phase 2 clinical trials completed. Not FDA approved. Widely used in performance and anti-aging contexts.
Approval Status
Phase2
Sports Legal
Restricted
References
- 1
CJC-1295, a long-acting GHRH analogue, increases GH and IGF-1 in healthy adults
2006
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.