CJC-1295
Research profile · How we handle evidence
A long-lasting growth hormone booster that keeps your GH levels elevated for days. Often combined with Ipamorelin for what many consider the holy grail anti-aging stack. The DAC version is what makes it last - without it, you're looking at a 30-minute half-life like regular GHRH.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
Without DAC: Daily. With DAC: 2x weekly
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Limited data
Overview
CJC-1295 no DAC (also called Mod GRF 1-29) gives you a natural 30-minute GH pulse that closely mimics your body's own rhythm. It's the cleaner approach compared to the DAC version, you inject before bed, get a nice GH surge during deep sleep, and your levels return to baseline by morning. This preserves your pituitary's sensitivity and avoids the GH bleed effect that can happen with DAC. Pair it with Ipamorelin for the most popular anti-aging peptide stack out there, they hit GH release from two complementary angles. Typical dosing is 100-200mcg at bedtime, and you'll notice better sleep within the first week, with body composition changes showing up around the 8-week mark.
Mechanism of Action
Growth hormone-releasing hormone analog that stimulates pituitary release of growth hormone without affecting prolactin levels. The DAC modification prevents degradation, extending half-life significantly.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- More muscle mass and strength over time
- Burns fat more efficiently
- Better quality sleep - deeper and more restorative
- Faster workout recovery
- Long-lasting effects - days not hours
Side Effects
- Water retention - especially in hands and feet
- Tingling or numbness in extremities
- Increased appetite
- Facial flushing
- Joint pain in some users
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
- Active cancer
- Uncontrolled diabetes
Structure & Sequence
Verified structure
CJC-1295
Illustration uses the catalog amino acid sequence because no exact external registry match was confirmed.
- Amino Acid Sequence
- Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 (mod GRF 1-29)
- Molecular Weight
- 3,367.9 Da
- Chemical Formula
- C152H252N44O42
- CAS Number
- 867305-54-0
- Reconstituted pH
- 10.9
Stack & Route Context
Stacks with
- Ipamorelin
- GHRP-2
- GHRP-6
- BPC-157
Administration
Subcutaneous
Research Status
Research peptide for growth hormone release. Shows promise in preclinical studies but requires more research. The DAC modification is what sets it apart from standard CJC.
Approval Status
Preclinical
Sports Legal
Restricted
References
- 1View source
CJC-1295, a long-acting GHRH analog
2006
- 2View source
Prolonged stimulation of growth hormone secretion
2006
- 3View source
Effects of extended release GHRH on GH and IGF-1 levels
2008
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.