cGP
Research profile · How we handle evidence
Cyclic Glycine-Proline peptide that modulates IGF-1 bioavailability and supports cognitive function.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
Daily
Half-life
Plasma elimination
Route
Oral or Subcutaneous
Safety Tier
Limited data
Overview
cGP (cyclic glycine-proline) is a small peptide found naturally in the body. Research describes it as a regulator of insulin-like growth factor 1 (IGF-1) function by changing how IGF-1 interacts with binding proteins, which can affect IGF-1 bioavailability. In animal and cell studies, cGP has been linked to IGF-1 activity in the brain and to memory-related outcomes—though this is still early-stage work. Practical note: cGP is discussed in the literature as orally bioavailable, which is one reason it draws attention from researchers.
Mechanism of Action
cGP (cyclic glycine-proline) is a small peptide found naturally in the body. Research describes it as a regulator of insulin-like growth factor 1 (IGF-1) function by changing how IGF-1 interacts with binding proteins, which can affect IGF-1 bioavailability. In animal and cell studies, cGP has been linked to IGF-1 activity in the brain and to memory-related outcomes—though this is still early-stage work. Practical note: cGP is discussed in the literature as orally bioavailable, which is one reason it draws attention from researchers.
Benefits
- Cognitive enhancement
- Memory support
- IGF-1 modulation
- Neuroprotection
Side Effects
- Generally well-tolerated
Contraindications
- Pregnant or breastfeeding women
Structure & Sequence
Verified structure
cGP
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- cyclo(Gly-Pro) — cyclic dipeptide
- Cyclization
- Cyclic (lactam) backbone
- Molecular Weight
- 154.17 Da
- Chemical Formula
- C7H10N2O2
- CAS Number
- N/A
- InChIKey
- OWOHLURDBZHNGG-YFKPBYRVSA-N
Stack & Route Context
Stacks with
- IGF-1 LR3
- Semax
Administration
Oral or Subcutaneous
Research Status
Research peptide for cognitive enhancement
Approval Status
Preclinical
Sports Legal
Permitted
References
- 1View source
Cyclic glycine-proline (cGP) — overview and IGF-1 binding discussion
2024
- 2View source
Cyclic glycine-proline regulates IGF-1 homeostasis by altering IGFBP-3 binding
2014
- 3View source
Cyclic glycine-proline Normalises IGF-1 function in the ageing brain and age-related neurological conditions
2023
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.