BPC-157
Research profile · How we handle evidence
BPC-157 (Body Protection Compound-157) is a 15–amino-acid peptide fragment originally identified in human gastric juice. In preclinical work, it has been studied for effects on wound healing and tissue repair in a range of models.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
1-2x daily
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Limited data
Overview
BPC-157 is a research peptide that’s been linked, mostly in animal studies, to faster-looking healing signals after injury. The strongest evidence base is preclinical, so any practical expectations should be conservative.
Mechanism of Action
Preclinical pathways discussed in the literature include FAK–paxillin signaling (linked to migration), growth-hormone receptor upregulation in fibroblasts, and nitric-oxide-related signaling that may support repair and vascular responses.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Heals stubborn tendon and ligament injuries that won't respond to rest
- Cuts systemic inflammation fast
- Repairs gut lining - especially helpful if you've damaged your stomach with NSAIDs
- Builds new blood vessels to damaged areas (angiogenesis)
- Protects and heals the stomach lining
- May help nerve tissue regenerate
Side Effects
- Injection-site irritation or soreness is the most commonly mentioned effect in limited user reports
- Transient flushing can occur, but documented cases are sparse
- No well-established side-effect profile in large human trials
Contraindications
- Pregnant or breastfeeding women
- Individuals under 18 years old
- Those with known allergies to peptide components
Structure & Sequence
Verified structure
BPC-157
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- GKPPPGKPADDAGLV
- Molecular Weight
- 1,419.5 Da
- Chemical Formula
- C62H98N16O22
- CAS Number
- 137525-51-0
- Reconstituted pH
- 6.4
- InChIKey
- HEEWEZGQMLZMFE-RKGINYAYSA-N
Stack & Route Context
Stacks with
- TB-500
- GHK-Cu
- Thymosin Alpha-1
Administration
Subcutaneous
Research Status
Research is largely preclinical, with limited human evidence. Effects reported in models are often framed around wound healing, inflammation modulation, and angiogenesis.
Approval Status
Preclinical
Sports Legal
Permitted
References
- 1View source
Pharmacokinetics, distribution, metabolism, and excretion of BPC 157 in rats and dogs
2022
- 2View source
Stable gastric pentadecapeptide BPC 157: Novel therapy in gastrointestinal tract
2016
- 3View source
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
2014
- 4View source
BPC 157 and standard angiogenic growth factors: Effects on inflammation and angiogenesis
2018
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.