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AOD-9604

Research profile · How we handle evidence

A piece of growth hormone designed just for fat burning. It helps break down fat without affecting blood sugar or causing muscle growth side effects. Very safe profile - FDA gave it GRAS status for a reason.

Evidence Score

86/100

High confidence

Category

Fat Loss

Therapeutic area

Standard Dose

250-500mcg

Once daily on empty stomach

Half-life

~6 hr

Plasma elimination

Route

SC

Subcutaneous

Safety Tier

1

Well characterized

Overview

Scientists took the fat-burning piece of growth hormone and isolated it. That's AOD-9604. It burns fat without the other effects of GH. No blood sugar issues, no weird growth, no water retention. Just pure fat loss. Great if you're sensitive to other fat loss compounds.

Mechanism of Action

Fragment of growth hormone (residues 176-191) that stimulates lipolysis and inhibits lipogenesis without affecting blood sugar or IGF-1 levels.

HGH Fragment 177 191 That Mimics Fat Burning Effects Without IGF 1 ElevationStimulates Lipolysis Through Beta 3 Adrenergic Receptor Activation In AdipocytesInhibits Fatty Acid Synthase, Reducing De Novo LipogenesisDoes Not Affect Blood Glucose, Insulin, Or IGF 1 Levels Unlike Full HGH

pH & Mixing

8.2

Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.

A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.

Benefits

  • Burns fat without other GH side effects
  • Stops your body from storing new fat
  • Does not affect blood sugar or insulin
  • May help with cartilage repair
  • Very safe - GRAS status

Side Effects

  • Minimal side effects overall
  • Well-tolerated by most people
  • Occasional injection site irritation

Contraindications

  • Pregnant or breastfeeding women
  • Individuals under 18 years old
  • Those with known allergies to peptide components

Structure & Sequence

View 3D structure

Verified structure

AOD-9604

Sequence illustration backed by PubChem match.

Verified via PubChemMatched by name
C78H123N23O23S21,815.1 DaCAS 158861-67-716 residues
Source: PubChemLookup: AOD-9604InChIKey GVIYUKXRXPXMQM-BPXGDYAESA-N
Amino Acid Sequence
YLRIVQCRSVEGSCGF (16aa, hGH 176-191 fragment with N-terminal Tyr)
Molecular Weight
1,815.1 Da
Chemical Formula
C78H123N23O23S2
CAS Number
158861-67-7
Reconstituted pH
8.2
InChIKey
GVIYUKXRXPXMQM-BPXGDYAESA-N

Stack & Route Context

Stacks with

  • BPC-157
  • Ipamorelin

Administration

Subcutaneous

Research Status

FDA GRAS status. TGA approved in Australia for osteoarthritis. Well-studied for fat loss applications with excellent safety record.

Approval Status

Approved

Sports Legal

Permitted

References

  1. 1

    AOD9604: a novel anti-obesity compound

    2001

    View source
  2. 2

    Effects of AOD9604 on adipose tissue

    2004

This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.

Research-driven insights.Evidence-based decisions.