Angiotensin (1-7)
Research profile · How we handle evidence
Angiotensin-(1-7) is an endogenous heptapeptide of the renin-angiotensin system, produced mainly by ACE2 acting on angiotensin II. It signals through the Mas receptor and counterbalances angiotensin II's vasoconstrictive, pro-inflammatory, and pro-fibrotic effects, giving it a cardioprotective and nephroprotective research profile.
Evidence Score
Preliminary signal
Category
Therapeutic area
Standard Dose
Research/clinical-trial context only
Half-life
Plasma elimination
Route
Subcutaneous or Intravenous
Safety Tier
Limited data
Overview
If angiotensin II is the 'gas pedal' of the renin-angiotensin system (raising blood pressure, promoting inflammation and fibrosis), angiotensin-(1-7) is closer to the 'brake' - it's generated from the same pathway but signals in the opposite direction. It has reached early-phase human trials (as TXA127/talfirastide) for cardiovascular and muscle-wasting conditions.
Mechanism of Action
If angiotensin II is the 'gas pedal' of the renin-angiotensin system (raising blood pressure, promoting inflammation and fibrosis), angiotensin-(1-7) is closer to the 'brake' - it's generated from the same pathway but signals in the opposite direction. It has reached early-phase human trials (as TXA127/talfirastide) for cardiovascular and muscle-wasting conditions.
Benefits
- Counterbalances angiotensin II-driven vasoconstriction and inflammation in preclinical models
- Studied for cardioprotective and nephroprotective effects
- Investigated in early-phase human trials (as TXA127/talfirastide) for cardiac and skeletal-muscle conditions
Side Effects
- Limited human safety data outside of clinical-trial settings
- Hypotension is a theoretical concern given its vasodilatory mechanism
- Not an established self-administration research peptide
Contraindications
- No established general human self-administration use - investigational/research only
- Not evaluated for pregnancy, pediatric, or long-term safety outside trial settings
Structure & Sequence
Verified structure
Angiotensin (1-7)
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- Asp-Arg-Val-Tyr-Ile-His-Pro (DRVYIHP)
- Molecular Weight
- 899.02 Da
- Chemical Formula
- C41H62N12O11
- InChIKey
- PVHLMTREZMEJCG-GDTLVBQBSA-N
Stack & Route Context
Stacks with
No entries listed.
Administration
Subcutaneous or Intravenous
Research Status
Extensive preclinical literature on the ACE2/Ang-(1-7)/Mas receptor axis, with completed Phase I/II trials in cancer, COVID-19, and ongoing trials in Duchenne muscular dystrophy cardiomyopathy and ischemic stroke recovery under the name TXA127 (talfirastide).
Approval Status
Phase 1/2 Clinical
Sports Legal
Permitted
References
- 1View source
Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Axis: Emerging Pharmacological Target for Pulmonary Diseases
2020
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.