AICAR
Research profile · How we handle evidence
AMP-activated protein kinase (AMPK) activator that mimics exercise effects and improves metabolic function.
Evidence Score
Preclinical signal
Category
Therapeutic area
Standard Dose
Daily
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Limited data
Overview
AICAR is basically exercise in a vial, it activates the same AMPK pathway that lights up when you're crushing a workout. This means your cells shift into fat-burning mode, your endurance climbs, and your metabolic health improves even on rest days. Endurance athletes and people dealing with metabolic syndrome are the main audience here. Start with 10-50mg daily for 4-8 week cycles, and you'll likely notice improved stamina and easier fat loss within a couple weeks. Pair it with MOTS-c for a broader mitochondrial and metabolic tune-up that really amplifies the exercise-mimetic effects.
Mechanism of Action
AICAR is basically exercise in a vial, it activates the same AMPK pathway that lights up when you're crushing a workout. This means your cells shift into fat-burning mode, your endurance climbs, and your metabolic health improves even on rest days. Endurance athletes and people dealing with metabolic syndrome are the main audience here. Start with 10-50mg daily for 4-8 week cycles, and you'll likely notice improved stamina and easier fat loss within a couple weeks. Pair it with MOTS-c for a broader mitochondrial and metabolic tune-up that really amplifies the exercise-mimetic effects.
Benefits
- Metabolic enhancement
- Fat burning
- Improved endurance
- Exercise mimetic effects
Side Effects
- Generally well-tolerated
- Possible mild nausea
Contraindications
No entries listed.
Structure & Sequence
Verified structure
AICAR
Exact 2D structure can be rendered from a PubChem-backed canonical SMILES string.
- Molecular Weight
- 338.21 Da
- Chemical Formula
- C9H15N4O8P
- CAS Number
- 3031-94-5
- InChIKey
- NOTGFIUVDGNKRI-UHFFFAOYSA-N
Stack & Route Context
Stacks with
- MOTS-c
- Cardarine
Administration
Subcutaneous
Research Status
Research compound for metabolic enhancement
Approval Status
Preclinical
Sports Legal
Permitted
References
- 1View source
AICAr, a widely used AMPK activator with important AMPK-independent effects (systematic review)
2021
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.