Abaloparatide
Research profile · How we handle evidence
Abaloparatide is a synthetic peptide related to parathyroid hormone-related protein (PTHrP). It is approved for certain patients with osteoporosis and is designed to stimulate new bone formation and improve bone density.
Evidence Score
High confidence
Category
Therapeutic area
Standard Dose
Daily
Half-life
Plasma elimination
Route
Subcutaneous
Safety Tier
Limited data
Overview
Think of abaloparatide as a medication that encourages the body to build new bone. Researchers and clinicians use it to help reduce fracture risk in people with severe osteoporosis, but results vary between individuals.
Mechanism of Action
Think of abaloparatide as a medication that encourages the body to build new bone. Researchers and clinicians use it to help reduce fracture risk in people with severe osteoporosis, but results vary between individuals.
pH & Mixing
Peptides reconstituted at very different pH levels can destabilize when combined in the same syringe, which lowers how much of the peptide your body actually absorbs. If you're unsure whether two peptides are close enough in pH, reconstitute and inject them separately.
A dedicated compatibility check between two specific peptides is coming to the Compare tool. This section covers this peptide's pH only.
Benefits
- Increased bone density
- Bone formation stimulation
- Fracture risk reduction
- Osteoporosis treatment
Side Effects
- Dizziness
- Nausea
- Headache
- Elevated calcium levels in some patients
Contraindications
- Pregnancy
- Bone cancer
- Hypercalcemia
- Paget's disease
Structure & Sequence
Verified structure
Abaloparatide
Sequence illustration backed by PubChem match.
- Amino Acid Sequence
- AVSEHQLLHDKGKSIQDLRRRELLEKLL-Aib-KLHTA-NH2 (34aa, PTHrP analog)
- Molecular Weight
- 3,961 Da
- Chemical Formula
- C174H300N56O49
- CAS Number
- N/A
- Reconstituted pH
- 5.1-5.2
- InChIKey
- BVISQZFBLRSESR-XSCWXTNMSA-N
Stack & Route Context
Stacks with
- Teriparatide
Administration
Subcutaneous
Research Status
FDA approved for osteoporosis treatment.
Approval Status
Approved
Sports Legal
Restricted
References
No references listed.
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.