RAD-140 (Testolone)
rad-one-forty
Category
Compound type
Phase / Status
Phase 1 clinical trials for breast cancer treatment. Not FDA approved. Research chemical. One of the most potent SARMs available.
Standard Dose
Once daily
Half-life
Plasma elimination
Route(s)
Intramuscular, Subcutaneous or Oral
Research Stage
Research phase not specified; exercise appropriate caution.
Overview
RAD-140 is considered one of the most potent SARMs available. It gives strong anabolic (muscle-building) effects with very low androgenic (masculinizing) side effects. It's being researched for breast cancer treatment and brain protection. Still experimental - not approved. Think of it as the 'heavy hitter' of SARMs - strong results but also strong suppression.
Plain-language summary
RAD-140 is considered one of the most potent SARMs available. It gives strong anabolic (muscle-building) effects with very low androgenic (masculinizing) side effects. It's being researched for breast cancer treatment and brain protection. Still experimental - not approved. Think of it as the 'heavy hitter' of SARMs - strong results but also strong suppression.
Administration Routes
- Intramuscular
- Subcutaneous
- Oral
Also known as
Mechanisms
Selective androgen receptor modulator with high anabolic-to-androgenic ratio (90:1). Activates androgen receptors in muscle and bone selectively. Basically turns on muscle-building genes without turning on the 'masculine' side effects.
Detailed mechanism
Selective androgen receptor modulator with high anabolic-to-androgenic ratio (90:1). Activates androgen receptors in muscle and bone selectively. Selectively binds to androgen receptors in muscle and bone tissue while minimizing effects on other organs, promoting anabolic effects with reduced side effects compared to traditional steroids.
Safety
Side effects
- Testosterone suppression (significant)
- Increased aggression
- Hair loss (at higher doses, DHT pathway)
- Potential liver enzyme elevation
- PCT required after cycle
Reported benefits
- Very high anabolic-to-androgenic ratio (90:1)
- Significant lean muscle mass gains
- Superior strength and power output
- Neuroprotective properties (being researched)
- Potential for breast cancer treatment
- Minimal water retention
Safety profile
Safety profile varies. Consult healthcare provider before use.
Clinical trials
Phase 1 clinical trials completed, establishing safety profile.
Structure
Verified structure
RAD-140 (Testolone)
Exact 2D structure can be rendered from a PubChem-backed canonical SMILES string.
- Chemical Formula
- C20H16ClN5O2
- Molecular Weight
- 393.83 g/mol
- CAS Number
- 1182367-47-0
- InChIKey
- XMBUPPIEVAFYHO-KPZWWZAWSA-N
Stack Context
Stacks with
Comparison context
RAD-140 is the strongest SARM for lean mass, stronger than Ostarine but more suppressive. Unlike LGD-4033, which adds mass with some water retention, RAD-140 produces a drier, harder look. Compared to traditional anabolic steroids like Anavar, RAD-140 is less hepatotoxic but still suppresses natural testosterone significantly.
References
- 1View source
RAD140, a selective androgen receptor modulator, reduces aggressive prostate tumor growth (Cancer Research)
2017
- 2View source
Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats (Endocrinology)
2014
- 3View source
Phase 1 first-in-human study of RAD-140 in hormone receptor-positive metastatic breast cancer (ClinicalTrials.gov)
2017
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.