Nolvadex (Nolvadex/NCT/Nolvadex Citrate)
NOL-vuh-dex
Category
Compound type
Phase / Status
FDA approved prescription medication with long-standing clinical use in oncology. Any endocrine-related use should be clinician-guided.
Standard Dose
Once or twice daily
Half-life
Plasma elimination
Route(s)
Intramuscular, Subcutaneous or Oral
Research Stage
Regulatory approval granted; post-market monitoring ongoing.
Overview
Nolvadex is a prescription medication that selectively affects estrogen receptors. In approved cancer settings it can reduce estrogen-driven growth of some tumors. It is not an over-the-counter supplement; dosing and monitoring should be clinician-directed.
Plain-language summary
Nolvadex is a prescription medication that selectively affects estrogen receptors. In approved cancer settings it can reduce estrogen-driven growth of some tumors. It is not an over-the-counter supplement; dosing and monitoring should be clinician-directed.
Administration Routes
- Intramuscular
- Subcutaneous
- Oral
Also known as
Mechanisms
Selective Estrogen Receptor Modulator (SERM): it blocks estrogen receptors in breast tissue and acts as an estrogen antagonist/partial agonist depending on tissue type. This can influence signaling in reproductive and endocrine pathways.
Detailed mechanism
Selective Estrogen Receptor Modulator (SERM): blocks estrogen receptors in breast tissue and modulates estrogen receptor signaling in other tissues, affecting endocrine pathways.
Safety
Side effects
- Hot flashes
- Mood changes
- Nausea or fatigue
- Rare risk of serious blood clots in susceptible individuals
- Laboratory/medical monitoring may be needed in treatment settings
Reported benefits
- Used in approved treatment/prevention of certain breast cancers
- Selective modulation of estrogen receptors in different tissues
- Well-studied prescription medication
Safety profile
Well-characterized safety profile in monitored clinical use. Risks depend on the patient and the indication.
Clinical trials
Completed clinical trials leading to FDA or regulatory approval in approved indications.
Structure
Verified structure
Nolvadex (Nolvadex/NCT/Nolvadex Citrate)
No exact public structure match was confirmed, so the app will render a formula-backed illustration.
- Chemical Formula
- C26H29ClNO2
- Molecular Weight
- 564.06 g/mol
- CAS Number
- 5496-12-0
Stack Context
Stacks with
Comparison context
Tamoxifen and other agents (e.g., aromatase inhibitors or SERMs) affect estrogen pathways differently and are chosen based on indication and clinical context.
References
- 1View source
Tamoxifen for testosterone restoration in males with hypogonadism (BJU International)
2005
- 2View source
Selective estrogen receptor modulators for male infertility (Fertility and Sterility)
2009
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.