MK-677 (Ibutamoren)
MK-six-seventy-seven
Category
Compound type
Phase / Status
Research chemical, not approved for human use
Standard Dose
Daily
Half-life
Plasma elimination
Route(s)
Oral
Research Stage
Research phase not specified; exercise appropriate caution.
Overview
As a ghrelin mimetic, MK-677 can increase appetite and may affect sleep and recovery. The same hormonal shifts can also promote water retention and may worsen insulin sensitivity, especially in people at higher metabolic risk. If you're considering any non-prescribed use, talk to a clinician and avoid relying on unsupervised online protocols.
Plain-language summary
As a ghrelin mimetic, MK-677 can increase appetite and may affect sleep and recovery. The same hormonal shifts can also promote water retention and may worsen insulin sensitivity, especially in people at higher metabolic risk. If you're considering any non-prescribed use, talk to a clinician and avoid relying on unsupervised online protocols.
Administration Routes
- Oral
Also known as
Mechanisms
Ghrelin receptor agonist
Detailed mechanism
Ghrelin receptor agonist that increases growth hormone and IGF-1 secretion without suppressing natural production.
Safety
Side effects
- Increased appetite
- Water retention
- Insulin resistance
- Lethargy
- Carpal tunnel
Reported benefits
- Increased GH/IGF-1
- Better sleep quality
- Muscle growth
- Faster recovery
- Improved skin/hair
Safety profile
Long-term safety unknown. May increase cancer risk. Use with caution.
Clinical trials
Limited human studies, mostly in elderly populations.
Structure
Verified structure
MK-677 (Ibutamoren)
No exact public structure match was confirmed, so the app will render a formula-backed illustration.
- Chemical Formula
- C28H37N5O2
- Molecular Weight
- 536.75 g/mol
- CAS Number
- 159724-78-6
Stack Context
Stacks with
References
- 1View source
Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults (Annals of Internal Medicine)
2008
- 2View source
Growth hormone secretagogue MK-677 in Alzheimer's disease: a randomized controlled trial (PubMed)
2009
- 3View source
MK-677 (ibutamoren mesylate) for growth hormone deficiency and muscle wasting: Phase 2 study (ClinicalTrials.gov)
2005
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.