GW-501516 (Cardarine)
gee-double-you-five-oh-one-five-one-six
Category
Compound type
Phase / Status
Development was discontinued after carcinogenicity findings in animal studies. There is no approved medical use. Research use only (non-medical).
Standard Dose
Once daily
Half-life
Plasma elimination
Route(s)
Oral
Research Stage
Research phase not specified; exercise appropriate caution.
Overview
Cardarine is a metabolic modulator that may shift energy use toward fat by activating PPARdelta. It has been promoted for endurance and fat-loss goals, but its development was halted due to cancer findings in animals at higher doses. If you are considering anything in this class, treat safety concerns as a primary issue and avoid relying on anecdotal claims.
Plain-language summary
Cardarine is a metabolic modulator that may shift energy use toward fat by activating PPARdelta. It has been promoted for endurance and fat-loss goals, but its development was halted due to cancer findings in animals at higher doses. If you are considering anything in this class, treat safety concerns as a primary issue and avoid relying on anecdotal claims.
Administration Routes
- Oral
Also known as
Mechanisms
PPARdelta (Peroxisome proliferator-activated receptor delta) agonist - activates genes involved in fatty-acid oxidation and energy metabolism. In practical terms, it can influence how cells use fats versus carbohydrates for energy.
Detailed mechanism
PPARdelta (Peroxisome proliferator-activated receptor delta) agonist - activates genes involved in fatty acid oxidation and energy metabolism. Modulates cellular pathways and enzyme activity to produce therapeutic effects at the molecular level.
Safety
Side effects
- Potential carcinogenic risk suggested by animal studies at high doses
- Possible liver stress or toxicity at higher exposures (reported in some user accounts)
- Headache
- Back pain
- Unknown long-term effects in humans
Reported benefits
- Dramatic endurance and cardiovascular improvement
- Significant fat burning and body fat reduction
- Improved lipid profile (increases HDL)
- Does NOT suppress testosterone (non-hormonal)
- Glucose regulation improvement
- Combines well with SARMs
Safety profile
Limited human safety data. Because of nonclinical cancer findings at higher doses, any consideration should be treated as high-risk and discussed with a qualified healthcare professional.
Clinical trials
Research studies ongoing. Not yet in formal clinical trials.
Structure
Verified structure
GW-501516 (Cardarine)
Exact 2D structure can be rendered from a PubChem-backed canonical SMILES string.
- Chemical Formula
- C21H18F3NO3S2
- Molecular Weight
- 453.49 g/mol
- CAS Number
- 317318-70-0
- InChIKey
- YDBLKRPLXZNVNB-UHFFFAOYSA-N
Stack Context
Stacks with
References
- 1View source
Regulation of muscle fiber type and running endurance by PPARdelta (Cell)
2004
- 2View source
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome (PNAS)
2003
- 3View source
Dangers of GW501516 (Cardarine) and why its development was discontinued - USADA advisory
2018
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.