GW-0742
GW-oh-74-2
Category
Compound type
Phase / Status
Research chemical only
Standard Dose
As directed
Half-life
Plasma elimination
Route(s)
Oral, Injectable or Topical
Research Stage
Research phase not specified; exercise appropriate caution.
Overview
GW-0742 is in the same research family as cardarine (GW-501516): both target the PPAR-delta pathway. The reason people talk about it is that PPAR-delta signaling is involved in how the body uses fuels, which is why the research focus often includes endurance and metabolic effects. The safety story is the hard part -- PPAR-delta agonists have shown cancer risk signals in preclinical studies, so this is not something to treat like a supplement.
Plain-language summary
GW-0742 is in the same research family as cardarine (GW-501516): both target the PPAR-delta pathway. The reason people talk about it is that PPAR-delta signaling is involved in how the body uses fuels, which is why the research focus often includes endurance and metabolic effects. The safety story is the hard part -- PPAR-delta agonists have shown cancer risk signals in preclinical studies, so this is not something to treat like a supplement.
Administration Routes
- Oral
- Injectable
- Topical
Also known as
Mechanisms
PPAR-delta (PPAR-beta/delta) agonist
Detailed mechanism
GW-0742 is a highly selective PPAR-delta (peroxisome proliferator-activated receptor delta) agonist that binds to the nuclear receptor with greater selectivity for the delta subtype compared to GW-501516. Upon binding, it activates transcriptional programs governing fatty acid beta-oxidation in skeletal muscle and shifts cellular energy utilization toward fat oxidation, which in animal models correlates with improved endurance capacity. Like other PPAR-delta agonists, it has demonstrated concerning tumor-promoting activity in long-term rodent carcinogenicity studies, and it has not entered human clinical trials.
Safety
Side effects
- Unknown in humans
- Potential cancer risk
Reported benefits
- Endurance enhancement
- Metabolic benefits
Safety profile
Consult medical professional before use
Clinical trials
See research status
Structure
Verified structure
GW-0742
Exact 2D structure can be rendered from a PubChem-backed canonical SMILES string.
- Chemical Formula
- C21H17F4NO3S2
- Molecular Weight
- 471.5 g/mol
- CAS Number
- 317318-84-6
- InChIKey
- HWVNEWGKWRGSRK-UHFFFAOYSA-N
Stack Context
No stack data available.
References
- 1View source
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport (PNAS)
2001
- 2View source
Rationally designed PPARdelta-specific agonists and their therapeutic potential for metabolic syndrome: preclinical cancer signal discussion (PMC)
2017
- 3View source
Dangers of GW501516 (Cardarine) and related PPARdelta agonists including GW0742 - USADA advisory
2018
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.