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SupplementPhase1

Fisetin

fy-SEH-tin

Research profile · How we handle evidence

Category

Supplement

Compound type

Phase / Status

Phase1

Natural flavonoid. Senolytic effects being studied in clinical trials. Promising but needs more human data.

Standard Dose

100-200mg daily or 1000-2000mg senolytic dose 2x/month

Daily low-dose or 2x monthly senolytic dose

Half-life

8-12 hours

Plasma elimination

Route(s)

OR

Oral

Research Stage

Status Unknown

Research phase not specified; exercise appropriate caution.

Overview

Fisetin is a plant compound. Researchers are interested in whether it can help reduce the buildup of senescent cells, which are linked to chronic inflammation and aging-related changes. The most consistent guidance is: start low, avoid stacking with unsafe combinations, and follow clinical study ranges -- don't assume that dosing for one purpose automatically applies to another.

Plain-language summary

Fisetin is a plant compound. Researchers are interested in whether it can help reduce the buildup of senescent cells, which are linked to chronic inflammation and aging-related changes. The most consistent guidance is: start low, avoid stacking with unsafe combinations, and follow clinical study ranges -- don't assume that dosing for one purpose automatically applies to another.

Administration Routes

  • Oral

Also known as

Strawberry extractSenolyticZombie cell killerLongevity flavonoidPlant senolyticFisAnti-aging flavonoid

Mechanisms

1

Flavonoid with senescence-related bioactivity studied for 'senolytic' effects. Reported pathways include modulation of stress-response signaling and Nrf2-linked antioxidant responses, along with downstream changes seen in senescent-cell models (exact mechanism can vary by study design).

Detailed mechanism

Senolytic flavonoid - clears senescent cells, inhibits p16 and p21 pathways, activates Nrf2 pathway. Modulates cellular pathways and enzyme activity to produce therapeutic effects at the molecular level.

Safety

Side effects

  • GI upset (nausea, stomach discomfort) can happen, especially at higher doses
  • Headache or fatigue are reported anecdotally
  • Stop and seek medical advice if you develop rash, unusual bruising/bleeding, or severe GI symptoms

Reported benefits

  • Eliminates senescent zombie cells
  • May extend lifespan (shown in mice)
  • Reduces systemic inflammation
  • Neuroprotective effects
  • Antioxidant properties
  • May improve cognitive function

Safety profile

Safety profile varies. Consult healthcare provider before use.

Clinical trials

Phase 1 clinical trials completed, establishing safety profile.

Structure

View 3D structure

Verified structure

Fisetin

Exact 2D structure can be rendered from a PubChem-backed canonical SMILES string.

Verified via PubChemMatched by casNumber
Source: PubChemLookup: 491-70-3InChIKey IQPNAANSBPBGFQ-UHFFFAOYSA-N
Chemical Formula
C15H10O6
Molecular Weight
272.24 g/mol
CAS Number
491-70-3
InChIKey
IQPNAANSBPBGFQ-UHFFFAOYSA-N

Stack Context

Stacks with

QuercetinMetforminNMN

References

  1. 1

    Fisetin is a senotherapeutic that extends health and lifespan (Cell Metab)

    2018

    View source
  2. 2

    Fisetin to alleviate senescence in older adults - pilot clinical trial (ClinicalTrials.gov NCT03430037)

    2021

    View source
  3. 3

    Cellular senescence: a translational perspective and emerging role of senolytics including flavonoids (EBioMedicine)

    2017

    View source

This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.

Research-driven insights.Evidence-based decisions.