Enclomiphene
en-klo-MIH-uh-feen
Category
Compound type
Phase / Status
Enclomiphene has been studied in clinical trials for hormone changes in men with functional hypogonadism. Available approvals and prescribing practices vary by country and by indication.
Standard Dose
Once daily or every other day
Half-life
Plasma elimination
Route(s)
Intramuscular, Subcutaneous or Oral
Research Stage
Research phase not specified; exercise appropriate caution.
Overview
Enclomiphene is a clomiphene isomer that modulates estrogen receptors. By lowering estrogen's "brake" on the brain, it can increase LH and FSH signals. Those signals can stimulate the testes to produce more testosterone (and can support fertility in some people with secondary hypogonadism). This is educational information, not medical advice.
Plain-language summary
Enclomiphene is a clomiphene isomer that modulates estrogen receptors. By lowering estrogen's "brake" on the brain, it can increase LH and FSH signals. Those signals can stimulate the testes to produce more testosterone (and can support fertility in some people with secondary hypogonadism). This is educational information, not medical advice.
Administration Routes
- Intramuscular
- Subcutaneous
- Oral
Also known as
Mechanisms
SERM (selective estrogen receptor modulator) action. Enclomiphene acts as an estrogen-receptor antagonist/partial modulator in the hypothalamus and pituitary, reducing estrogen negative feedback. With less feedback, the pituitary can increase LH and FSH output, which stimulates gonadal steroidogenesis and spermatogenesis.
Detailed mechanism
Selective Estrogen Receptor Modulator (SERM). Enclomiphene modulates estrogen receptors in the hypothalamus/pituitary, reducing estrogen negative feedback. This can increase LH and FSH release, which then signals the testes to increase testosterone production and may support spermatogenesis.
Safety
Side effects
- Headache
- Nausea or stomach upset
- Fatigue
- Mood changes (reported in some studies/clinical use)
- Visual symptoms (uncommon but important -- stop and seek urgent medical advice if they occur)
- Possible changes in liver enzymes in some people
Reported benefits
- May raise LH and FSH in people whose signaling is suppressed
- May increase endogenous testosterone in selected cases
- Can be discussed as part of fertility-preserving strategies (varies by individual)
- Oral administration
- Used/under study under clinician guidance in some regions
Safety profile
Commonly reported effects include headache, nausea/stomach upset, and fatigue. Mood changes and visual symptoms have been reported; visual symptoms are a safety red flag -- seek urgent medical advice if they occur. Liver enzyme changes have been observed in some people. This entry is for education only and does not replace clinician guidance.
Clinical trials
Clinical trials have evaluated enclomiphene for hormone changes in men with functional/secondary hypogonadism.
Structure
Verified structure
Enclomiphene
Exact 2D structure can be rendered from a PubChem-backed canonical SMILES string.
- Chemical Formula
- C26H28ClNO
- Molecular Weight
- 362.46 g/mol
- CAS Number
- 50-41-9 (cis-isomer)
- InChIKey
- GKIRPKYJQBWNGO-OCEACIFDSA-N
Stack Context
Stacks with
References
- 1View source
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II trial (J Urol)
2014
- 2View source
Clomiphene or enclomiphene citrate for male hypogonadism: systematic review and meta-analysis of randomized trials
2024
- 3View source
Androxal (enclomiphene citrate) for restoration of testosterone in men with secondary hypogonadism - Phase 3 trial (ClinicalTrials.gov NCT01207570)
2012
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.