Andarine (S4)
AN-dar-een
Category
Compound type
Phase / Status
Development suspended by GSK. Limited evidence exists and it is not approved for medical use.
Standard Dose
Once or twice daily
Half-life
Plasma elimination
Route(s)
Intramuscular, Subcutaneous or Oral
Research Stage
Research phase not specified; exercise appropriate caution.
Overview
Andarine is often marketed as a cutting-focused SARM. It's discussed for helping preserve lean mass while reducing fat. A key drawback reported by some users is the possibility of vision-related side effects (such as yellow tint or light sensitivity). Use only with appropriate medical oversight and caution.
Plain-language summary
Andarine is often marketed as a cutting-focused SARM. It's discussed for helping preserve lean mass while reducing fat. A key drawback reported by some users is the possibility of vision-related side effects (such as yellow tint or light sensitivity). Use only with appropriate medical oversight and caution.
Administration Routes
- Intramuscular
- Subcutaneous
- Oral
Also known as
Mechanisms
Selective androgen receptor modulator (SARM). Binds to androgen receptors in muscle and bone tissue and is intended to have more targeted activity than non-selective anabolic steroids.
Detailed mechanism
Selective androgen receptor modulator (SARM) — binds to androgen receptors in muscle and bone tissue while minimizing effects on other organs (based on the intended selectivity of SARMs). Human safety data remains limited.
Safety
Side effects
- Vision-related effects (e.g., yellow tint, light sensitivity)
- Potential testosterone suppression (dose- and duration-dependent)
- Possible effects on lipids (e.g., HDL reduction)
- Hair loss in genetically susceptible individuals
- Fatigue at higher exposures
Reported benefits
- Supports lean-mass goals during a cut (varies by individual)
- May be associated with "hard"/dry appearance
- Oral administration
- Potentially less water retention than some anabolic steroids
Safety profile
Limited human safety data. Use should be approached cautiously, with professional supervision and monitoring when possible.
Clinical trials
Research studies exist, but it is not yet broadly supported by formal clinical protocols for general use.
Structure
Verified structure
Andarine (S4)
No exact public structure match was confirmed, so the app will render a formula-backed illustration.
- Chemical Formula
- C21H21FN4O
- Molecular Weight
- 371.46 g/mol
- CAS Number
- 2006263-53-1
Stack Context
Stacks with
References
- 1View source
Chemistry and structural biology of androgen receptor (Chem Rev)
2005
- 2View source
Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs) (Drug Discov Today)
2007
- 3View source
Selective androgen receptor modulators in preclinical and clinical development (Nucl Recept Signal)
2008
This profile summarizes research literature for education only. It is not medical advice, and it does not diagnose, treat, or recommend a dose. Consult a qualified professional before changing a protocol.